Two plant-derived aporphinoid alkaloids exert their antifungal activity by disrupting mitochondrial iron-sulfur cluster biosynthesis

Eupolauridine and liriodenine are plant-derived aporphinoid alkaloids that exhibit potent inhibitory activity against the opportunistic fungal pathogens Candida albicans and Cryptococcus neoformans. However, the molecular mechanism of this antifungal activity is unknown. In this study, we show that...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Tripathi, Siddharth K., Xu, Tao, Feng, Qin, Avula, Bharathi, Shi, Xiaomin, Pan, Xuewen, Mask, Melanie M., Baerson, Scott R., Jacob, Melissa R., Ravu, Ranga Rao, Khan, Shabana I., Li, Xing-Cong, Khan, Ikhlas A., Clark, Alice M., Agarwal, Ameeta K.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2017
Sujets:
Metabolism
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5633121/
https://ncbi.nlm.nih.gov/pubmed/28821607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.781773
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