Two plant-derived aporphinoid alkaloids exert their antifungal activity by disrupting mitochondrial iron-sulfur cluster biosynthesis

Eupolauridine and liriodenine are plant-derived aporphinoid alkaloids that exhibit potent inhibitory activity against the opportunistic fungal pathogens Candida albicans and Cryptococcus neoformans. However, the molecular mechanism of this antifungal activity is unknown. In this study, we show that...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Tripathi, Siddharth K., Xu, Tao, Feng, Qin, Avula, Bharathi, Shi, Xiaomin, Pan, Xuewen, Mask, Melanie M., Baerson, Scott R., Jacob, Melissa R., Ravu, Ranga Rao, Khan, Shabana I., Li, Xing-Cong, Khan, Ikhlas A., Clark, Alice M., Agarwal, Ameeta K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5633121/
https://ncbi.nlm.nih.gov/pubmed/28821607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.781773
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