Two plant-derived aporphinoid alkaloids exert their antifungal activity by disrupting mitochondrial iron-sulfur cluster biosynthesis

Eupolauridine and liriodenine are plant-derived aporphinoid alkaloids that exhibit potent inhibitory activity against the opportunistic fungal pathogens Candida albicans and Cryptococcus neoformans. However, the molecular mechanism of this antifungal activity is unknown. In this study, we show that...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Tripathi, Siddharth K., Xu, Tao, Feng, Qin, Avula, Bharathi, Shi, Xiaomin, Pan, Xuewen, Mask, Melanie M., Baerson, Scott R., Jacob, Melissa R., Ravu, Ranga Rao, Khan, Shabana I., Li, Xing-Cong, Khan, Ikhlas A., Clark, Alice M., Agarwal, Ameeta K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2017
Schlagworte:
Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5633121/
https://ncbi.nlm.nih.gov/pubmed/28821607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.781773
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