A Potent Plant-Derived Antifungal Acetylenic Acid Mediates Its Activity by Interfering with Fatty Acid Homeostasis

6-Nonadecynoic acid (6-NDA), a plant-derived acetylenic acid, exhibits strong inhibitory activity against the human fungal pathogens Candida albicans, Aspergillus fumigatus, and Trichophyton mentagrophytes. In the present study, transcriptional profiling coupled with mutant and biochemical analyses...

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Detalhes bibliográficos
Main Authors: Xu, Tao, Tripathi, Siddharth K., Feng, Qin, Lorenz, Michael C., Wright, Marsha A., Jacob, Melissa R., Mask, Melanie M., Baerson, Scott R., Li, Xing-Cong, Clark, Alice M., Agarwal, Ameeta K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370752/
https://ncbi.nlm.nih.gov/pubmed/22430960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05663-11
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