The Marine Sponge-Derived Polyketide Endoperoxide Plakortide F Acid Mediates Its Antifungal Activity by Interfering with Calcium Homeostasis

Plakortide F acid (PFA), a marine-derived polyketide endoperoxide, exhibits strong inhibitory activity against the opportunistic fungal pathogens Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus. In the present study, transcriptional profiling coupled with mutant and biochemical...

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Autors principals: Xu, Tao, Feng, Qin, Jacob, Melissa R., Avula, Bharathi, Mask, Melanie M., Baerson, Scott R., Tripathi, Siddharth K., Mohammed, Rabab, Hamann, Mark T., Khan, Ikhlas A., Walker, Larry A., Clark, Alice M., Agarwal, Ameeta K.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2011
Matèries:
Mechanisms of Action: Physiological Effects
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067192/
https://ncbi.nlm.nih.gov/pubmed/21300833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01022-10
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