The Marine Sponge-Derived Polyketide Endoperoxide Plakortide F Acid Mediates Its Antifungal Activity by Interfering with Calcium Homeostasis

Plakortide F acid (PFA), a marine-derived polyketide endoperoxide, exhibits strong inhibitory activity against the opportunistic fungal pathogens Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus. In the present study, transcriptional profiling coupled with mutant and biochemical...

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Detalhes bibliográficos
Main Authors: Xu, Tao, Feng, Qin, Jacob, Melissa R., Avula, Bharathi, Mask, Melanie M., Baerson, Scott R., Tripathi, Siddharth K., Mohammed, Rabab, Hamann, Mark T., Khan, Ikhlas A., Walker, Larry A., Clark, Alice M., Agarwal, Ameeta K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2011
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067192/
https://ncbi.nlm.nih.gov/pubmed/21300833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01022-10
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