A Potent Plant-Derived Antifungal Acetylenic Acid Mediates Its Activity by Interfering with Fatty Acid Homeostasis

6-Nonadecynoic acid (6-NDA), a plant-derived acetylenic acid, exhibits strong inhibitory activity against the human fungal pathogens Candida albicans, Aspergillus fumigatus, and Trichophyton mentagrophytes. In the present study, transcriptional profiling coupled with mutant and biochemical analyses...

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Bibliografiske detaljer
Main Authors: Xu, Tao, Tripathi, Siddharth K., Feng, Qin, Lorenz, Michael C., Wright, Marsha A., Jacob, Melissa R., Mask, Melanie M., Baerson, Scott R., Li, Xing-Cong, Clark, Alice M., Agarwal, Ameeta K.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2012
Fag:
Mechanisms of Action: Physiological Effects
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370752/
https://ncbi.nlm.nih.gov/pubmed/22430960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05663-11
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