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Novel xanthone-polyamine conjugates as catalytic inhibitors of human topoisomerase IIα
It has been proposed that xanthone derivatives with anticancer potential act as topoisomerase II inhibitors because they interfere with the ability of the enzyme to bind its ATP cofactor. In order to further characterize xanthone mechanism and generate compounds with potential as anticancer drugs, w...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5623067/ https://ncbi.nlm.nih.gov/pubmed/28919339 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.09.011 |
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