DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg(2+)-mediated dynamic bending of gate-DNA

Topoisomerase II resolves intrinsic topological problems of double-stranded DNA. As part of its essential cellular functions, the enzyme generates DNA breaks, but the regulation of this potentially dangerous process is not well understood. Here we report single-molecule fluorescence experiments that...

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Detaylı Bibliyografya
Asıl Yazarlar: Lee, Sanghwa, Jung, Seung-Ryoung, Heo, Kang, Byl, Jo Ann W., Deweese, Joseph E., Osheroff, Neil, Hohng, Sungchul
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2012
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286967/
https://ncbi.nlm.nih.gov/pubmed/22323612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1115704109
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