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DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg(2+)-mediated dynamic bending of gate-DNA
Topoisomerase II resolves intrinsic topological problems of double-stranded DNA. As part of its essential cellular functions, the enzyme generates DNA breaks, but the regulation of this potentially dangerous process is not well understood. Here we report single-molecule fluorescence experiments that...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3286967/ https://ncbi.nlm.nih.gov/pubmed/22323612 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1115704109 |
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