Selection of DNA Cleavage Sites by Topoisomerase II Results from Enzyme-induced Flexibility of DNA

Topoisomerase II cleaves DNA at preferred sequences with different efficiencies; however, the mechanism of cleavage site selection is not known. Here we used single-molecule fluorescence assays that monitor several critical steps of DNA-topoisomerase II interactions, including binding/dissociation,...

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Gepubliceerd in:Cell Chem Biol
Hoofdauteurs: Jang, Yunsu, Son, Heyjin, Lee, Sang-Wook, Hwang, Wonseok, Jung, Seung-Ryoung, Byl, Jo Ann W., Osheroff, Neil, Lee, Sanghwa
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6474810/
https://ncbi.nlm.nih.gov/pubmed/30713098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2018.12.003
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