Selection of DNA Cleavage Sites by Topoisomerase II Results from Enzyme-induced Flexibility of DNA

Topoisomerase II cleaves DNA at preferred sequences with different efficiencies; however, the mechanism of cleavage site selection is not known. Here we used single-molecule fluorescence assays that monitor several critical steps of DNA-topoisomerase II interactions, including binding/dissociation,...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:Cell Chem Biol
Glavni autori: Jang, Yunsu, Son, Heyjin, Lee, Sang-Wook, Hwang, Wonseok, Jung, Seung-Ryoung, Byl, Jo Ann W., Osheroff, Neil, Lee, Sanghwa
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6474810/
https://ncbi.nlm.nih.gov/pubmed/30713098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2018.12.003
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items