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IMPACT OF THE C-TERMINAL DOMAIN OF TOPOISOMERASE IIα ON THE DNA CLEAVAGE ACTIVITY OF THE HUMAN ENZYME

The enzymatic function of the C-terminal domain of eukaryotic topoisomerase II is not well defined. This region of the enzyme is highly variable, hydrophilic, and contains nuclear localization signals and phosphorylation sites. In contrast to eukaryotic topoisomerase II, type II enzymes from chlorel...

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Bibliographic Details
Main Authors: Dickey, Jennifer S., Osheroff, Neil
Format: Artigo
Language:Inglês
Published: 2005
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2678941/
https://ncbi.nlm.nih.gov/pubmed/16114891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi050811l
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