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IMPACT OF THE C-TERMINAL DOMAIN OF TOPOISOMERASE IIα ON THE DNA CLEAVAGE ACTIVITY OF THE HUMAN ENZYME
The enzymatic function of the C-terminal domain of eukaryotic topoisomerase II is not well defined. This region of the enzyme is highly variable, hydrophilic, and contains nuclear localization signals and phosphorylation sites. In contrast to eukaryotic topoisomerase II, type II enzymes from chlorel...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2678941/ https://ncbi.nlm.nih.gov/pubmed/16114891 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi050811l |
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