Novel, Potent, and Druglike Tetrahydroquinazoline Inhibitor That Is Highly Selective for Human Topoisomerase II α over β

[Image: see text] We disclose a novel class of 6-amino-tetrahydroquinazoline derivatives that inhibit human topoisomerase II (topoII), a validated target of anticancer drugs. In contrast to topoII-targeted drugs currently in clinical use, these compounds do not act as topoII poisons that enhance enz...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:J Med Chem
Main Authors: Ortega, Jose Antonio, Arencibia, Jose M., Minniti, Elirosa, Byl, Jo Ann W., Franco-Ulloa, Sebastian, Borgogno, Marco, Genna, Vito, Summa, Maria, Bertozzi, Sine Mandrup, Bertorelli, Rosalia, Armirotti, Andrea, Minarini, Anna, Sissi, Claudia, Osheroff, Neil, De Vivo, Marco
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2020
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7668297/
https://ncbi.nlm.nih.gov/pubmed/33079544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00774
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker