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Novel, Potent, and Druglike Tetrahydroquinazoline Inhibitor That Is Highly Selective for Human Topoisomerase II α over β
[Image: see text] We disclose a novel class of 6-amino-tetrahydroquinazoline derivatives that inhibit human topoisomerase II (topoII), a validated target of anticancer drugs. In contrast to topoII-targeted drugs currently in clinical use, these compounds do not act as topoII poisons that enhance enz...
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發表在: | J Med Chem |
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Main Authors: | , , , , , , , , , , , , , , |
格式: | Artigo |
語言: | Inglês |
出版: |
American Chemical
Society
2020
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在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7668297/ https://ncbi.nlm.nih.gov/pubmed/33079544 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00774 |
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