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Novel xanthone-polyamine conjugates as catalytic inhibitors of human topoisomerase IIα

It has been proposed that xanthone derivatives with anticancer potential act as topoisomerase II inhibitors because they interfere with the ability of the enzyme to bind its ATP cofactor. In order to further characterize xanthone mechanism and generate compounds with potential as anticancer drugs, w...

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Publicat a:Bioorg Med Chem Lett
Autors principals: Minniti, Elirosa, Byl, Jo Ann W., Riccardi, Laura, Sissi, Claudia, Rosini, Michela, De Vivo, Marco, Minarini, Anna, Osheroff, Neil
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5623067/
https://ncbi.nlm.nih.gov/pubmed/28919339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.09.011
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