Photo-affinity labelling and biochemical analyses identify the target of trypanocidal simplified natural product analogues

Current drugs to treat African sleeping sickness are inadequate and new therapies are urgently required. As part of a medicinal chemistry programme based upon the simplification of acetogenin-type ether scaffolds, we previously reported the promising trypanocidal activity of compound 1, a bis-tetrah...

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Veröffentlicht in:PLoS Negl Trop Dis
Hauptverfasser: Tulloch, Lindsay B., Menzies, Stefanie K., Fraser, Andrew L., Gould, Eoin R., King, Elizabeth F., Zacharova, Marija K., Florence, Gordon J., Smith, Terry K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5608556/
https://ncbi.nlm.nih.gov/pubmed/28873407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0005886
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