Structure‐Based Design, Synthesis and Biological Evaluation of Bis‐Tetrahydropyran Furan Acetogenin Mimics Targeting the Trypanosomatid F1 Component of ATP Synthase

The protozoan parasites Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp. are responsible for the severely debilitating neglected Tropical diseases of African sleeping sickness, Chagas disease and leishmaniasis, respectively. As part of our ongoing programme exploring the potential of simpli...

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Detalhes bibliográficos
Publicado no:European J Org Chem
Main Authors: Zacharova, Marija K., Tulloch, Lindsay B., Gould, Eoin R., Fraser, Andrew L., King, Elizabeth F., Menzies, Stefanie K., Smith, Terry K., Florence, Gordon J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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Full Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6774295/
https://ncbi.nlm.nih.gov/pubmed/31598093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ejoc.201900541
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