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Non-natural acetogenin analogues as potent Trypanosoma brucei inhibitors
A series of novel bis-tetrahydropyran 1,4-triazole analogues based on the acetogenin framework display low micromolar trypanocidal activities towards both bloodstream and insect forms of Trypanosoma brucei, the causative agent of African sleeping sickness. A divergent synthetic strategy was adopted...
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| Publié dans: | ChemMedChem |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4298241/ https://ncbi.nlm.nih.gov/pubmed/25145275 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201402272 |
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