Non-natural acetogenin analogues as potent Trypanosoma brucei inhibitors

A series of novel bis-tetrahydropyran 1,4-triazole analogues based on the acetogenin framework display low micromolar trypanocidal activities towards both bloodstream and insect forms of Trypanosoma brucei, the causative agent of African sleeping sickness. A divergent synthetic strategy was adopted...

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Publicado en:ChemMedChem
Main Authors: Florence, Gordon J., Fraser, Andrew L., Gould, Eoin R., King, Elizabeth F., Menzies, Stefanie K., Morris, Joanne C., Tulloch, Lindsay B., Smith, Terry K.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4298241/
https://ncbi.nlm.nih.gov/pubmed/25145275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201402272
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