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Podophyllotoxin Analogues Active versus Trypanosoma brucei

In an effort to discover novel anti-trypanosomal compounds, a series of podophyllotoxin analogues coupled to non-steroidal anti-inflammatory drugs (NSAIDs) has been synthesized and evaluated for activity versus Trypanosoma brucei and a panel of human cell lines, revealing compounds with low nano-mol...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Uddin, Md. Jashim, Smithson, David C., Brown, Kristin M., Crews, Brenda C., Connelly, Michele, Zhu, Fangyi, Marnett, Lawrence J., Guy, R. Kiplin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2826502/
https://ncbi.nlm.nih.gov/pubmed/20129783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.01.009
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