The 2′-Trifluoromethyl Analogue of Indomethacin Is a Potent and Selective COX-2 Inhibitor

[Image: see text] Indomethacin is a potent, time-dependent, nonselective inhibitor of the cyclooxygenase enzymes (COX-1 and COX-2). Deletion of the 2′-methyl group of indomethacin produces a weak, reversible COX inhibitor, leading us to explore functionality at that position. Here, we report that su...

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Autores principales: Blobaum, Anna L., Uddin, Md. Jashim, Felts, Andrew S., Crews, Brenda C., Rouzer, Carol A., Marnett, Lawrence J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2013
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3654564/
https://ncbi.nlm.nih.gov/pubmed/23687559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400066a
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