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ortho-Carbaborane Derivatives of Indomethacin as Cyclooxygenase (COX)-2 Selective Inhibitors

A series of novel indomethacin analogues with carbaboranes as three-dimensional substitutes for the chlorophenyl ring have been prepared. Their cyclooxygenase (COX) inhibition and enzyme selectivity has been tested and compared to the corresponding adamantyl analogues. Surprisingly, only the ortho-c...

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Detaylı Bibliyografya
Asıl Yazarlar: Scholz, Matthias, Blobaum, Anna L., Marnett, Lawrence J., Hey-Hawkins, Evamarie
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408963/
https://ncbi.nlm.nih.gov/pubmed/22748709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.05.063
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