Conjugation of Cisplatin Analogues and Cyclooxygenase Inhibitors to Overcome Cisplatin Resistance

Cyclooxygenase (COX) is an enzyme involved in tumorigenesis and is associated with tumor cell resistance against platinum-based antitumor drugs. Cisplatin analogues were conjugated with COX inhibitors (indomethacin, ibuprofen) to study the synergistic effects that were previously observed in combina...

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Detalhes bibliográficos
Publicado no:ChemMedChem
Main Authors: Neumann, Wilma, Crews, Brenda C., Sárosi, Menyhárt B., Daniel, Cristina M., Ghebreselasie, Kebreab, Scholz, Matthias S., Marnett, Lawrence J., Hey-Hawkins, Evamarie
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4480879/
https://ncbi.nlm.nih.gov/pubmed/25318459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201402353
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