nido-Dicarbaborate Induces Potent and Selective Inhibition of Cyclooxygenase-2()

Carbaboranes are increasingly studied as pharmacophores, particularly as replacements for aromatic systems. However, especially ortho-carbaborane is prone to degradation of the cluster, which hampers biological application. This study demonstrates that deboronation of the cluster may not only lead t...

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Veröffentlicht in:ChemMedChem
Hauptverfasser: Neumann, Wilma, Xu, Shu, Sárosi, Menyhárt B., Scholz, Matthias S., Crews, Brenda C., Ghebreselasie, Kebreab, Banerjee, Surajit, Marnett, Lawrence J., Hey-Hawkins, Evamarie
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4900168/
https://ncbi.nlm.nih.gov/pubmed/26088701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201500199
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