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2-Carbaborane-3-phenyl-1H-indoles – Synthesis via McMurry Reaction and COX Inhibition Activity

Cyclooxygenase-2 (COX-2) inhibitors have been in the focus of medicinal chemistry for years and many compounds exhibiting high selectivity and affinity were developed. As carbaboranes represent interesting pharmacophores as phenyl mimetics in drug development, this paper presents the synthesis of ca...

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Main Authors: Laube, Markus, Neumann, Wilma, Scholz, Matthias, Lönnecke, Peter, Crews, Brenda, Marnett, Lawrence J., Pietzsch, Jens, Kniess, Torsten, Hey-Hawkins, Evamarie
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3849512/
https://ncbi.nlm.nih.gov/pubmed/23303738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201200455
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