In vivo activation of latent HIV with a synthetic bryostatin analog effects both latent cell "kick" and "kill" in strategy for virus eradication

The ability of HIV to establish a long-lived latent infection within resting CD4+ T cells leads to persistence and episodic resupply of the virus in patients treated with antiretroviral therapy (ART), thereby preventing eradication of the disease. Protein kinase C (PKC) modulators such as bryostatin...

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Foilsithe in:PLoS Pathog
Main Authors: Marsden, Matthew D., Loy, Brian A., Wu, Xiaomeng, Ramirez, Christina M., Schrier, Adam J., Murray, Danielle, Shimizu, Akira, Ryckbosch, Steven M., Near, Katherine E., Chun, Tae-Wook, Wender, Paul A., Zack, Jerome A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2017
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5608406/
https://ncbi.nlm.nih.gov/pubmed/28934369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006575
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