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Designed, Synthetically Accessible Bryostatin Analogues Potently Induce Activation of Latent HIV Reservoirs in vitro

Bryostatin is a unique lead in the development of potentially transformative therapies for cancer, Alzheimer’s disease, and the eradication of HIV/AIDS. However, the clinical use of bryostatin has been hampered by its limited supply, difficulties in accessing clinically-relevant derivatives, and sid...

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Detalhes bibliográficos
Main Authors: DeChristopher, Brian A., Loy, Brian A., Marsden, Matthew D., Schrier, Adam J., Zack, Jerome A., Wender, Paul A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428736/
https://ncbi.nlm.nih.gov/pubmed/22914190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchem.1395
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