Discovery of a Potent Inhibitor Class with High Selectivity toward Clostridial Collagenases

[Image: see text] Secreted virulence factors like bacterial collagenases are conceptually attractive targets for fighting microbial infections. However, previous attempts to develop potent compounds against these metalloproteases failed to achieve selectivity against human matrix metalloproteinases...

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Publié dans:J Am Chem Soc
Auteurs principaux: Schönauer, Esther, Kany, Andreas M., Haupenthal, Jörg, Hüsecken, Kristina, Hoppe, Isabel J., Voos, Katrin, Yahiaoui, Samir, Elsässer, Brigitta, Ducho, Christian, Brandstetter, Hans, Hartmann, Rolf W.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2017
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5607459/
https://ncbi.nlm.nih.gov/pubmed/28820255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b06935
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