Discovery of a Potent Inhibitor Class with High Selectivity toward Clostridial Collagenases

[Image: see text] Secreted virulence factors like bacterial collagenases are conceptually attractive targets for fighting microbial infections. However, previous attempts to develop potent compounds against these metalloproteases failed to achieve selectivity against human matrix metalloproteinases...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Schönauer, Esther, Kany, Andreas M., Haupenthal, Jörg, Hüsecken, Kristina, Hoppe, Isabel J., Voos, Katrin, Yahiaoui, Samir, Elsässer, Brigitta, Ducho, Christian, Brandstetter, Hans, Hartmann, Rolf W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5607459/
https://ncbi.nlm.nih.gov/pubmed/28820255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b06935
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