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Discovery of a Potent Inhibitor Class with High Selectivity toward Clostridial Collagenases
[Image: see text] Secreted virulence factors like bacterial collagenases are conceptually attractive targets for fighting microbial infections. However, previous attempts to develop potent compounds against these metalloproteases failed to achieve selectivity against human matrix metalloproteinases...
Salvato in:
| Pubblicato in: | J Am Chem Soc |
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| Autori principali: | , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Chemical
Society
2017
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5607459/ https://ncbi.nlm.nih.gov/pubmed/28820255 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b06935 |
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