Discovery of a Potent Inhibitor Class with High Selectivity toward Clostridial Collagenases

[Image: see text] Secreted virulence factors like bacterial collagenases are conceptually attractive targets for fighting microbial infections. However, previous attempts to develop potent compounds against these metalloproteases failed to achieve selectivity against human matrix metalloproteinases...

Full description

Saved in:
Bibliographic Details
Published in:J Am Chem Soc
Main Authors: Schönauer, Esther, Kany, Andreas M., Haupenthal, Jörg, Hüsecken, Kristina, Hoppe, Isabel J., Voos, Katrin, Yahiaoui, Samir, Elsässer, Brigitta, Ducho, Christian, Brandstetter, Hans, Hartmann, Rolf W.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2017
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5607459/
https://ncbi.nlm.nih.gov/pubmed/28820255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b06935
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items