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A novel in silico framework to improve MHC-I epitopes and break the tolerance to melanoma
Tolerance toward tumor antigens, which are shared by normal tissues, have often limited the efficacy of cancer vaccines. However, wild type epitopes can be tweaked to activate cross-reactive T-cell clones, resulting in antitumor activity. The design of these analogs (i.e., heteroclitic peptides) can...
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| 出版年: | Oncoimmunology |
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| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Taylor & Francis
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5599093/ https://ncbi.nlm.nih.gov/pubmed/28932628 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1319028 |
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