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The Evolution of Adenoviral Vectors through Genetic and Chemical Surface Modifications
A long time has passed since the first clinical trial with adenoviral (Ad) vectors. Despite being very promising, Ad vectors soon revealed their limitations in human clinical trials. The pre-existing immunity, the marked liver tropism and the high toxicity of first generation Ad (FG-Ad) vectors have...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3939484/ https://ncbi.nlm.nih.gov/pubmed/24549268 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v6020832 |
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