A novel in silico framework to improve MHC-I epitopes and break the tolerance to melanoma

Tolerance toward tumor antigens, which are shared by normal tissues, have often limited the efficacy of cancer vaccines. However, wild type epitopes can be tweaked to activate cross-reactive T-cell clones, resulting in antitumor activity. The design of these analogs (i.e., heteroclitic peptides) can...

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Sparad:
Bibliografiska uppgifter
I publikationen:Oncoimmunology
Huvudupphovsmän: Capasso, Cristian, Magarkar, Aniket, Cervera-Carrascon, Victor, Fusciello, Manlio, Feola, Sara, Muller, Martin, Garofalo, Mariangela, Kuryk, Lukasz, Tähtinen, Siri, Pastore, Lucio, Bunker, Alex, Cerullo, Vincenzo
Materialtyp: Artigo
Språk:Inglês
Publicerad: Taylor & Francis 2017
Ämnen:
Original Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599093/
https://ncbi.nlm.nih.gov/pubmed/28932628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1319028
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