A novel in silico framework to improve MHC-I epitopes and break the tolerance to melanoma

Tolerance toward tumor antigens, which are shared by normal tissues, have often limited the efficacy of cancer vaccines. However, wild type epitopes can be tweaked to activate cross-reactive T-cell clones, resulting in antitumor activity. The design of these analogs (i.e., heteroclitic peptides) can...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Capasso, Cristian, Magarkar, Aniket, Cervera-Carrascon, Victor, Fusciello, Manlio, Feola, Sara, Muller, Martin, Garofalo, Mariangela, Kuryk, Lukasz, Tähtinen, Siri, Pastore, Lucio, Bunker, Alex, Cerullo, Vincenzo
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599093/
https://ncbi.nlm.nih.gov/pubmed/28932628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1319028
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