A novel in silico framework to improve MHC-I epitopes and break the tolerance to melanoma

Tolerance toward tumor antigens, which are shared by normal tissues, have often limited the efficacy of cancer vaccines. However, wild type epitopes can be tweaked to activate cross-reactive T-cell clones, resulting in antitumor activity. The design of these analogs (i.e., heteroclitic peptides) can...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Oncoimmunology
Prif Awduron: Capasso, Cristian, Magarkar, Aniket, Cervera-Carrascon, Victor, Fusciello, Manlio, Feola, Sara, Muller, Martin, Garofalo, Mariangela, Kuryk, Lukasz, Tähtinen, Siri, Pastore, Lucio, Bunker, Alex, Cerullo, Vincenzo
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Taylor & Francis 2017
Pynciau:
Original Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599093/
https://ncbi.nlm.nih.gov/pubmed/28932628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1319028
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