PDI is an essential redox-sensitive activator of PERK during the unfolded protein response (UPR)

Endoplasmic reticulum (ER) stress leads to activation of the unfolded protein response (UPR) that results in transient suppression of protein translation to allow recovery but leads to cell death when stress cannot be resolved. Central to initiation of the UPR is the activation of the ER transmembra...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Kranz, Philip, Neumann, Fabian, Wolf, Alexandra, Classen, Fabian, Pompsch, Mosche, Ocklenburg, Tobias, Baumann, Jennifer, Janke, Kirsten, Baumann, Melanie, Goepelt, Kirsten, Riffkin, Helena, Metzen, Eric, Brockmeier, Ulf
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596557/
https://ncbi.nlm.nih.gov/pubmed/28796255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.369
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