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Overcoming hypoxia-induced resistance of pancreatic and lung tumor cells by disrupting the PERK-NRF2-HIF-axis

Hypoxia-induced resistance of tumor cells to therapeutic treatment is an unresolved limitation due to poor vascular accessibility and protective cell adaptations provided by a network, including PERK, NRF2, and HIF signaling. All three pathways have been shown to influence each other, but a detailed...

詳細記述

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書誌詳細
出版年:Cell Death Dis
主要な著者: Küper, Alina, Baumann, Jennifer, Göpelt, Kirsten, Baumann, Melanie, Sänger, Christopher, Metzen, Eric, Kranz, Philip, Brockmeier, Ulf
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2021
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7806930/
https://ncbi.nlm.nih.gov/pubmed/33441543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03319-7
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