Depletion of the thiol oxidoreductase ERp57 in tumor cells inhibits proliferation and increases sensitivity to ionizing radiation and chemotherapeutics

Rapidly growing tumor cells must synthesize proteins at a high rate and therefore depend on an efficient folding and quality control system for nascent secretory proteins in the endoplasmic reticulum (ER). The ER resident thiol oxidoreductase ERp57 plays an important role in disulfide bond formation...

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Udgivet i:Oncotarget
Main Authors: Hussmann, Melanie, Janke, Kirsten, Kranz, Philip, Neumann, Fabian, Mersch, Evgenija, Baumann, Melanie, Goepelt, Kirsten, Brockmeier, Ulf, Metzen, Eric
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770770/
https://ncbi.nlm.nih.gov/pubmed/26513173
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