PDI is an essential redox-sensitive activator of PERK during the unfolded protein response (UPR)

Endoplasmic reticulum (ER) stress leads to activation of the unfolded protein response (UPR) that results in transient suppression of protein translation to allow recovery but leads to cell death when stress cannot be resolved. Central to initiation of the UPR is the activation of the ER transmembra...

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Dettagli Bibliografici
Pubblicato in:Cell Death Dis
Autori principali: Kranz, Philip, Neumann, Fabian, Wolf, Alexandra, Classen, Fabian, Pompsch, Mosche, Ocklenburg, Tobias, Baumann, Jennifer, Janke, Kirsten, Baumann, Melanie, Goepelt, Kirsten, Riffkin, Helena, Metzen, Eric, Brockmeier, Ulf
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596557/
https://ncbi.nlm.nih.gov/pubmed/28796255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.369
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