PDI is an essential redox-sensitive activator of PERK during the unfolded protein response (UPR)

Endoplasmic reticulum (ER) stress leads to activation of the unfolded protein response (UPR) that results in transient suppression of protein translation to allow recovery but leads to cell death when stress cannot be resolved. Central to initiation of the UPR is the activation of the ER transmembra...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Death Dis
Prif Awduron: Kranz, Philip, Neumann, Fabian, Wolf, Alexandra, Classen, Fabian, Pompsch, Mosche, Ocklenburg, Tobias, Baumann, Jennifer, Janke, Kirsten, Baumann, Melanie, Goepelt, Kirsten, Riffkin, Helena, Metzen, Eric, Brockmeier, Ulf
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2017
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596557/
https://ncbi.nlm.nih.gov/pubmed/28796255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.369
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