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Tumor cells rely on the thiol oxidoreductase PDI for PERK signaling in order to survive ER stress

Upon ER stress cells activate the unfolded protein response through PERK, IRE1 and ATF6. Remarkable effort has been made to delineate the downstream signaling of these three ER stress sensors after activation, but upstream regulation at the ER luminal site still remains mostly undefined. Here we rep...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kranz, Philip, Sänger, Christopher, Wolf, Alexandra, Baumann, Jennifer, Metzen, Eric, Baumann, Melanie, Göpelt, Kirsten, Brockmeier, Ulf
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7499200/
https://ncbi.nlm.nih.gov/pubmed/32943707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-72259-1
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