Tumor cells rely on the thiol oxidoreductase PDI for PERK signaling in order to survive ER stress

Upon ER stress cells activate the unfolded protein response through PERK, IRE1 and ATF6. Remarkable effort has been made to delineate the downstream signaling of these three ER stress sensors after activation, but upstream regulation at the ER luminal site still remains mostly undefined. Here we rep...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Kranz, Philip, Sänger, Christopher, Wolf, Alexandra, Baumann, Jennifer, Metzen, Eric, Baumann, Melanie, Göpelt, Kirsten, Brockmeier, Ulf
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7499200/
https://ncbi.nlm.nih.gov/pubmed/32943707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-72259-1
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