The presumed MTH1-inhibitor TH588 sensitizes colorectal carcinoma cells to ionizing radiation in hypoxia

BACKGROUND: The nudix family member enzyme MutT homologue-1 (MTH1) hydrolyses the oxidized nucleotides 8-oxo-dGTP and 2-hydroxy-dATP and thus prevents the incorporation of damaged nucleotides into nuclear and mitochondrial DNA. Therefore MTH1 was proposed to protect cancer cells from oxidative DNA l...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:BMC Cancer
Egile Nagusiak: Pompsch, Mosche, Vogel, Julia, Classen, Fabian, Kranz, Philip, Iliakis, George, Riffkin, Helena, Brockmeier, Ulf, Metzen, Eric
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2018
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6267833/
https://ncbi.nlm.nih.gov/pubmed/30497423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-5095-x
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