Identification of NRAS isoform 2 overexpression as a mechanism facilitating BRAF inhibitor resistance in malignant melanoma

Activating mutations in BRAF are found in 50% of melanomas and although treatment with BRAF inhibitors (BRAFi) is effective, resistance often develops. We now show that recently discovered NRAS isoform 2 is up-regulated in the setting of BRAF inhibitor resistance in melanoma, in both cell lines and...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Duggan, Megan C., Stiff, Andrew R., Bainazar, Maryam, Regan, Kelly, Olaverria Salavaggione, Gonzalo N., Maharry, Sophia, Blachly, James S., Krischak, Madison, Walker, Christopher J., Latchana, Nicholas, Tridandapani, Susheela, de la Chapelle, Albert, Eisfeld, Ann-Kathrin, Carson, William E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5594655/
https://ncbi.nlm.nih.gov/pubmed/28827320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1704371114
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