Identification of NRAS isoform 2 overexpression as a mechanism facilitating BRAF inhibitor resistance in malignant melanoma

Activating mutations in BRAF are found in 50% of melanomas and although treatment with BRAF inhibitors (BRAFi) is effective, resistance often develops. We now show that recently discovered NRAS isoform 2 is up-regulated in the setting of BRAF inhibitor resistance in melanoma, in both cell lines and...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Duggan, Megan C., Stiff, Andrew R., Bainazar, Maryam, Regan, Kelly, Olaverria Salavaggione, Gonzalo N., Maharry, Sophia, Blachly, James S., Krischak, Madison, Walker, Christopher J., Latchana, Nicholas, Tridandapani, Susheela, de la Chapelle, Albert, Eisfeld, Ann-Kathrin, Carson, William E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2017
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5594655/
https://ncbi.nlm.nih.gov/pubmed/28827320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1704371114
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