NRAS mRNA is differentially spliced to give five distinct isoforms: implications for melanoma therapy

NRAS is a commonly mutated oncogene in melanoma and therapeutic targeting of NRAS has proven difficult. We characterized the expression and phenotypic functions of 5 recently discovered splice isoforms of NRAS in melanoma. Canonical NRAS (isoform-1) was expressed to the highest degree and its expres...

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Bibliografiska uppgifter
I publikationen:Melanoma Res
Huvudupphovsmän: Duggan, Megan C, Regan, Kelly, Olaverria Salavaggione, Gonzalo N, Howard, J. Harrison, Stiff, Andrew R, Sabella, Julia, Latchana, Nicholas, Markowitz, Joseph, Gru, Alejandro, Tridandapani, Susheela, Eisfeld, Ann-Kathrin, de la Chapelle, Albert, Carson, William E
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2019
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7088457/
https://ncbi.nlm.nih.gov/pubmed/31116161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CMR.0000000000000623
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