NRAS isoforms differentially affect downstream pathways, cell growth, and cell transformation

Neuroblastoma rat sarcoma (RAS) viral oncogene homolog (NRAS), a small GTPase, is one of the most thoroughly studied oncogenes that controls cell growth, differentiation, and survival by facilitating signal transduction. Here, we identify four novel naturally occurring NRAS isoforms (isoforms 2–5) i...

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Hlavní autoři: Eisfeld, Ann-Kathrin, Schwind, Sebastian, Hoag, Kevin W., Walker, Christopher J., Liyanarachchi, Sandya, Patel, Ravi, Huang, Xiaomeng, Markowitz, Joseph, Duan, Wenrui, Otterson, Gregory A., Carson, William E., Marcucci, Guido, Bloomfield, Clara D., de la Chapelle, Albert
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3964043/
https://ncbi.nlm.nih.gov/pubmed/24586049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1401727111
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