NRAS isoforms differentially affect downstream pathways, cell growth, and cell transformation

Neuroblastoma rat sarcoma (RAS) viral oncogene homolog (NRAS), a small GTPase, is one of the most thoroughly studied oncogenes that controls cell growth, differentiation, and survival by facilitating signal transduction. Here, we identify four novel naturally occurring NRAS isoforms (isoforms 2–5) i...

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Detalhes bibliográficos
Main Authors: Eisfeld, Ann-Kathrin, Schwind, Sebastian, Hoag, Kevin W., Walker, Christopher J., Liyanarachchi, Sandya, Patel, Ravi, Huang, Xiaomeng, Markowitz, Joseph, Duan, Wenrui, Otterson, Gregory A., Carson, William E., Marcucci, Guido, Bloomfield, Clara D., de la Chapelle, Albert
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3964043/
https://ncbi.nlm.nih.gov/pubmed/24586049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1401727111
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