ATP-competitive, marine derived natural products that target the DEAD box helicase, eIF4A

Activation of translation initiation is a common trait of cancer cells. Formation of the heterotrimeric eukaryotic initiation factor F (eIF4F) complex is the rate-limiting step in 5′ m7GpppN cap-dependent translation. This trimeric complex includes the eIF4E cap binding protein, the eIF4G scaffoldin...

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Publié dans:Bioorg Med Chem Lett
Auteurs principaux: Tillotson, Joseph, Kedzior, Magdalena, Guimarães, Larissa, Ross, Alison B., Peters, Tara L., Ambrose, Andrew J., Schmidlin, Cody J., Zhang, Donna D., Costa-Lotufo, Letícia V., Rodríguez, Abimael D., Schatz, Jonathan H., Chapman, Eli
Format: Artigo
Langue:Inglês
Publié: 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5593424/
https://ncbi.nlm.nih.gov/pubmed/28757063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.07.045
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