Coupling between the DEAD-box RNA helicases Ded1p and eIF4A

Eukaryotic translation initiation involves two conserved DEAD-box RNA helicases, eIF4A and Ded1p. Here we show that S. cerevisiae eIF4A and Ded1p directly interact with each other and simultaneously with the scaffolding protein eIF4G. We delineate a comprehensive thermodynamic framework for the inte...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Gao, Zhaofeng, Putnam, Andrea A, Bowers, Heath A, Guenther, Ulf-Peter, Ye, Xuan, Kindsfather, Audrey, Hilliker, Angela K, Jankowsky, Eckhard
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Biochemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4990422/
https://ncbi.nlm.nih.gov/pubmed/27494274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.16408
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