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ATP-competitive, marine derived natural products that target the DEAD box helicase, eIF4A
Activation of translation initiation is a common trait of cancer cells. Formation of the heterotrimeric eukaryotic initiation factor F (eIF4F) complex is the rate-limiting step in 5′ m7GpppN cap-dependent translation. This trimeric complex includes the eIF4E cap binding protein, the eIF4G scaffoldin...
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發表在: | Bioorg Med Chem Lett |
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Main Authors: | , , , , , , , , , , , |
格式: | Artigo |
語言: | Inglês |
出版: |
2017
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主題: | |
在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5593424/ https://ncbi.nlm.nih.gov/pubmed/28757063 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.07.045 |
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