Synthesis, high-throughput screening and pharmacological characterization of β–lactam derivatives as TRPM8 antagonists

The mammalian transient receptor potential melastatin channel 8 (TRPM8), highly expressed in trigeminal and dorsal root ganglia, mediates the cooling sensation and plays an important role in the cold hypersensitivity characteristic of some types of neuropathic pain, as well as in cancer. Consequentl...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Sci Rep
Main Authors: de la Torre-Martínez, Roberto, Bonache, M. Angeles, Llabrés-Campaner, Pedro J., Balsera, Beatriz, Fernández-Carvajal, Asia, Fernández-Ballester, Gregorio, Ferrer-Montiel, Antonio, Pérez de Vega, M. Jesús, González-Muñiz, Rosario
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2017
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589751/
https://ncbi.nlm.nih.gov/pubmed/28883526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10913-x
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares