Synthesis, high-throughput screening and pharmacological characterization of β–lactam derivatives as TRPM8 antagonists

The mammalian transient receptor potential melastatin channel 8 (TRPM8), highly expressed in trigeminal and dorsal root ganglia, mediates the cooling sensation and plays an important role in the cold hypersensitivity characteristic of some types of neuropathic pain, as well as in cancer. Consequentl...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:Sci Rep
Hoofdauteurs: de la Torre-Martínez, Roberto, Bonache, M. Angeles, Llabrés-Campaner, Pedro J., Balsera, Beatriz, Fernández-Carvajal, Asia, Fernández-Ballester, Gregorio, Ferrer-Montiel, Antonio, Pérez de Vega, M. Jesús, González-Muñiz, Rosario
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2017
Onderwerpen:
Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589751/
https://ncbi.nlm.nih.gov/pubmed/28883526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10913-x
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items