Synthesis, high-throughput screening and pharmacological characterization of β–lactam derivatives as TRPM8 antagonists

The mammalian transient receptor potential melastatin channel 8 (TRPM8), highly expressed in trigeminal and dorsal root ganglia, mediates the cooling sensation and plays an important role in the cold hypersensitivity characteristic of some types of neuropathic pain, as well as in cancer. Consequentl...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: de la Torre-Martínez, Roberto, Bonache, M. Angeles, Llabrés-Campaner, Pedro J., Balsera, Beatriz, Fernández-Carvajal, Asia, Fernández-Ballester, Gregorio, Ferrer-Montiel, Antonio, Pérez de Vega, M. Jesús, González-Muñiz, Rosario
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589751/
https://ncbi.nlm.nih.gov/pubmed/28883526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10913-x
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