Phenylalanine-Derived β-Lactam TRPM8 Modulators. Configuration Effect on the Antagonist Activity

Transient receptor potential cation channel subfamily M member 8 (TRPM8) is a Ca(2+) non-selective ion channel implicated in a variety of pathological conditions, including cancer, inflammatory and neuropathic pain. In previous works we identified a family of chiral, highly hydrophobic β–lactam deri...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Bonache, María Ángeles, Llabrés, Pedro Juan, Martín-Escura, Cristina, De la Torre-Martínez, Roberto, Medina-Peris, Alicia, Butrón, Laura, Gómez-Monterrey, Isabel, Roa, Ana María, Fernández-Ballester, Gregorio, Ferrer-Montiel, Antonio, Fernández-Carvajal, Asia, González-Muñiz, Rosario
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7956626/
https://ncbi.nlm.nih.gov/pubmed/33673444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22052370
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